MiRNA target mimicry collection published
Document Actions
Blake C Meyers, Michael J Axtell, Bonnie Bartel, David P Bartel, David Baulcombe, John L Bowman, Xiaofeng Cao, James C Carrington, Xuemei Chen, Pamela J Green, Sam Griffiths-Jones, Steven E Jacobsen, Allison C Mallory, Robert A Martienssen, R S Poethig, Yijun Qi, Herve Vaucheret, Olivier Voinnet, Yuichiro Watanabe, Detlef Weigel, and Jian-Kang Zhu (2008)
Criteria for annotation of plant MicroRNAs.
Plant Cell, 20(12):3186-90.
MicroRNAs (miRNAs) are approximately 21 nucleotide noncoding RNAs produced by Dicer-catalyzed excision from stem-loop precursors. Many plant miRNAs play critical roles in development, nutrient homeostasis, abiotic stress responses, and pathogen responses via interactions with specific target mRNAs. miRNAs are not the only Dicer-derived small RNAs produced by plants: A substantial amount of the total small RNA abundance and an overwhelming amount of small RNA sequence diversity is contributed by distinct classes of 21- to 24-nucleotide short interfering RNAs. This fact, coupled with the rapidly increasing rate of plant small RNA discovery, demands an increased rigor in miRNA annotations. Herein, weupdate the specific criteria required for the annotation of plant miRNAs, including experimental and computational data, as well as refinements to standard nomenclature.
